雄激素受体和心型脂肪酸结合蛋白在心肌梗死者心肌中的表达

doi:10.16467/j.1008-3650.2019.06.007

刑事技术 ›› 2019, Vol. 44 ›› Issue (6) : 507-511. DOI: 10.16467/j.1008-3650.2019.06.007

论著

雄激素受体和心型脂肪酸结合蛋白在心肌梗死者心肌中的表达

张曙光¹, 王显慧², 苏丽娟¹, 贾富全¹, 荣荣¹, 刘长海^1,*

作者信息 +

Expression of Androgen Receptor and Heart-type Fatty Acid Binding Protein in Infarcted Myocardia

ZHANG Shuguang¹, WANG Xianhui², SU Lijuan¹, JIA Fuquan¹, RONG Rong¹, LIU Changhai^1,*

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History +

摘要

目的通过比较心肌梗死猝死组与正常对照组心肌组织中雄激素受体（AR）和心型脂肪酸结合蛋白（H-FABP）的表达以及相关研究,探讨二者与心肌梗死猝死之间的关系,为心肌梗死的法医病理学诊断提供客观依据。方法从内蒙古医科大学司法鉴定中心2011年至2014年尸检案例中筛选心肌梗死猝死者42例（实验组）、无冠心病其他死因者20例（对照组）,采用免疫组化SP法分别检测AR和H-FABP在心肌组织中的表达。结果 1）AR在实验组和对照组心肌组织中表达情况相比较,两组之间有显著差异（P <0.05）;2）H-FABP在实验组和对照组心肌组织中表达情况相比较,两组之间有显著差异（P <0.05）。结论心肌梗死猝死者冠状动脉和心肌组织中AR表达明显降低,可为心肌梗死猝死死后诊断提供参考依据。H-FABP在梗死心肌组织中表达明显降低,有望为心肌梗死法医学诊断提供参考依据。

Abstract

Objective To explore the correlation between heart-type fatty acid binding protein (H-FABP) or androgen receptor (AR) and sudden death after myocardial infarction through comparing the expression of AR and H-FABP in the group of sudden death of myocardial infarction against the control group so that an objective basis might be provided for forensic pathological diagnosis of myocardial infarction. Methods 42 cases of sudden death of myocardial infarction (the experimental group) and 20 cases of death of non-coronary disease (control group) were selected from the autopsied cadavers collected during 2011 to 2014 by the judicial identification center of Inner Mongolia medical university. The expressions of both AR and H-FABP in cardiac tissues from either the experimental or control group were detected with immuno-histochemical SP method. Results A significant difference was revealed in the expression of both AR and H-FABP between the experimental and control group (both of P<0.05). Conclusion The expression of AR was significantly reduced in both the coronary arteries and myocardial tissues of the cadavers died suddenly of myocardial infarction, suggesting that AR has protective effect to the cardiovascular system, capable of providing reference for the postmortem diagnosis of myocardial infarction. The expression of H-FABP was also significantly decreased in the infarcted myocardia, therefore eligible for a postmortem diagnostic indicator about myocardial infarction, too.

导出引用

张曙光, 王显慧, 苏丽娟, 贾富全, 荣荣, 刘长海. 雄激素受体和心型脂肪酸结合蛋白在心肌梗死者心肌中的表达. 刑事技术. 2019, 44(6): 507-511 https://doi.org/10.16467/j.1008-3650.2019.06.007

ZHANG Shuguang, WANG Xianhui, SU Lijuan, JIA Fuquan, RONG Rong, LIU Changhai. Expression of Androgen Receptor and Heart-type Fatty Acid Binding Protein in Infarcted Myocardia. Forensic Science and Technology. 2019, 44(6): 507-511 https://doi.org/10.16467/j.1008-3650.2019.06.007

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基金

内蒙古自治区高等学校科学技术研究项目（No.NJZY108）; 内蒙古医科大学青年创新基金项目（No.YKD2016QNCX016）

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2018-01-31	2018-08-01	2019-12-15
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2019-12-16

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