调查新疆和田地区哈萨克族人群23个STR基因座的遗传多态性。除D13S317基因座外,其他22个STR基因座的基因分布均符合Hardy-Weinberg平衡（P>0.05）。23个基因座的TDP达1-4.53×1029,CPE达0.999 999 999 804。23个STR基因座在新疆和田地区的哈萨克族人群中有较高的多态性,所得的群体遗传学数据可为该地区的法医学个体识别、亲权鉴定提供基础数据。
Abstract
The genetic polymorphism of 23 short tandem repeat (STR) loci of 1130 unrelated Kazak individuals in Hotan area of Xinjiang, was investigated with GoldeneyeTM24A PCR amplification Kit and the population genetics parameters were calculated with PowerStats statistic software. 22 loci were found no deviation from Hardy-Weinberg equilibrium (P>0.05) except D13S317 locus. Matching probability (PM) ranged from 0.0113 to 0.2035 together with the power of discrimination (DP) 0.7965 to 0.9887, polymorphism information content (PIC) 0.5688 to 0.9208, power of exclusion (PE) 0.3355 to 0.8408, heterozygosity (He) 0.6354 to 0.9221. The total discrimination power (TDP) and the combined power of exclusion (CPE) of 23 loci were 1-4.53×1029 and 0.999 999 999 804, respectively. The 23 STR loci were highly polymorphic in Kazak population of Hotan area. The polymorphic information would serve as reference data for forensic personal identification and paternity testing.
关键词
法医物证学 /
STR基因座 /
等位基因频率 /
遗传多态性 /
哈萨克族
{{custom_keyword}} /
Key words
forensic biological evidence /
STR loci /
allelic frequencies /
polymorphism /
Kazak population
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] 姜成涛,叶健,赵兴春,等．复合扩增18个基因座的初步研究[J] ．刑事技术,2007(5):7-8．
[2] 郝红蕾,吴微微,任文彦,等．15个STR基因座的突变观察和分析[J] ．刑事技术,2013(1):10-12．
[3] 侯巧芳,高放,桂宏胜,等．达斡尔民族X染色体遗传多态性与亲缘的关系[J] ．第四军医大学学报,2007,28(11): 1045-1048．
[4] Fung WK, Hu YQ. Statistical DNA forensics: Theory, methods and computation [M] . John Wiley & Sons, 2008:55-60.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
