Objective To study an analytical method for determination of lincomycin in blood.Methods The samples were extracted by SPE and then analyzed by HPLC with ACQUITY UPLC○R HSS T3 column and electron spray ionization.Results Average recovery rate of lincomycin ranged from 104.98 to 120.74%. Based on a signal-to-noise ratio of 3∶1, the detection limit was 55.4 pg/ ml.Conclusion This method is sensitive, accurate and can be used in casework.
Key words
lincomycin /
UPLC-MS/MS /
blood /
solid-phase extraction
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 国家药典委员会编. 中国药典[S]. 北京:化学工业出版社, 2010.
[2] 谢丽琪,岳振峰,唐少冰,等.高效液相色谱串联质谱法测定牛奶中林可酰胺类和大环内酯类抗生素残留量的研究[J].分析试验室,2008,27(3):5-8.
[3] 徐锦忠,吴忠贤,杨雯筌,等.液相色谱-电喷雾串联质谱测定蜂蜜中8种大环内酯类药物残留[J].分析化学,2007,35(2):166-170.
[4] 左志辉,高立勤,唐素芳. 固相萃取-液相色谱串联质谱法同时定量检测蜂蜜中28种抗生素类药物残留的研究[J].药物分析杂志,2009, 29(7): 1196-1201.
[5] 刘正才,杨方,等. 超高效液相色谱串联质谱法测定鳗鱼中大环内酯类和林可酰胺类抗生素残留量的研究[J].福建分析测试,2010,19(3):1-5.
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}