Objective To provide a extraction，purification and instrumental analysis method for the determination of basic abuse drugs in decay organism samples．Methods Abuse drugs extracted from organism samples by liquid-liquid and solid phase extraction were detected and quantified with GC／MS and GC／NPD．Using cyclohexane as the extracted solvent。and the Bond-Elut Certify cartridge columns were washed with methanol，and eluted by dichloromethane：isopropyl alcohol：ammonium hydmxide (78：20：2，v／v／v)mixed solvent．Results The morphine。codeine，estazolam and promethazine were all simultaneously detected from liver，stomach，heart blood and urine of the dead．And the drug concentration in Iiver was morphine 0．094μ9／g，codeine 0．257μg／g，and promethazine 0．110μg／g，in urine was morphine 0．334μ9／ml，codeine 4．054μg／ml，and promethazine 0．066μ9／ ml，and in heart blood was morphine 0．036μg／ml，codeine 0．106μg／mL，and promethazine 0．088μg／mL Conclution This method is nicety，reliable，and scientific，and it can be used in the analysis of kinds of basic drugs in organism samples in forensic toxicology．