LI Peng, HE Jianfeng, LIU Kelin, ZHANG Chunshui, GAO Lisheng, ZHENG Hui
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In the past decades, an ever-increasing number of new psychoactive substances (NPSs) have appeared in the recreational drug market, and analytical toxicologists have to continuously adapt new screening Methods to identify the latest NPSs. The daunting challenges are how to accurately monitor the state of NPSs and how to determine an enormous range of trace and ultra-trace analytes present in sample matrixes with complex or variable compositions. Here we present a critical overview of the analysis of some of the most commonly encountered and most dangerous substances. The rational method development, validation and transfer of robust gas chromatography-mass spectrometry (GC-MS), and important factors impacting the incurred sample analysis are discussed. The mature technologies coupled with GC-MS used in most quantitative bioanalytical laboratories, such as hollow fiber-based liquid phase microextraction (HF-LPME), electrosorption-enhanced solid-phase microextraction (EE-SPME), are also covered. Liquid phase separation techniques coupled with mass spectrometry (LC-MS), is also expounded in this paper. Due to its high specificity, speed and selectivity, LC-MS has long been deployed in NPSs detection to assess not only these continuously changing molecules but also their metabolites, and will probably surpass GC-MS as the leader of the so-called hyphenated techniques in the near future. Further challenges presented are to make sure that new methodologies and equipment comply with the principles of sustainable development, so in the third part, some new techniques, triple quadrupole time-of-flight mass spectrometer (QQQ-TOF-MS), graphite screen-printed electrode (GSPE) and among others, are discussed as well. Finally, one of the key issues, highlighted from future perspective, is to narrow the time gap between the first appearance of an NPS and the availability of reference standards of parent drugs and metabolites. Otherwise, the identification of NPSs and/or their metabolites will remain preliminary.